Abstract
This investigation aimed to determine the effect of a multi-ingredient pre-workout supplement (MIPS) on heart rate (HR), perceived exertion (RPE), lactate concentration, and time to fatigue (TTF) during a running task to volitional exhaustion. Eleven NCAA Division I cross-country runners (20 ± 2 year; height: 171 ± 14 cm; weight: 63.5 ± 9.1 kg) participated in this randomized, double-blind, placebo-controlled cross-over study. Bayesian statistical methods were utilized, and parameter estimates were interpreted as statistically significant if the 95% highest-density intervals (HDIs) did not include zero. TTF was increased in the MIPS condition with a posterior Meandiff = 154 ± 4.2 s (95% HDI: −167, 465) and a 0.84 posterior probability that the supplement would increase TTF relative to PL. Blood lactate concentration immediately post-exercise was also higher in the MIPS condition compared to PL with an estimated posterior Meandiff = 3.99 ± 2.1 mmol (95% HDI: −0.16, 7.68). There were no differences in HR or RPE between trials. These findings suggest that a MIPS ingested prior to sustained running at lactate threshold has an 84% chance of increasing TTF in highly trained runners and may allow athletes to handle a higher level of circulating lactate before reaching exhaustion.
Highlights
Multi-ingredient pre-workout supplements (MIPSs) are a subcategory of sports nutrition products formulated to enhance metabolic, physiological, and psychological function during exercise
Time to fatigue was increased in the MIPS-PE condition with an estimated posterior Meandiff = 154 ± 4.2 s (95% highest-density intervals (HDIs): −167, 465) and moderate effect size estimate of 0.46 (95% HDI: −0.48, 1.53)
The current investigation results showed that the ingestion of MIPS-PE effectively increased time to fatigue (TTF) in highly trained runners at an intensity equivalent to their lactate threshold compared to a PL control
Summary
Multi-ingredient pre-workout supplements (MIPSs) are a subcategory of sports nutrition products formulated to enhance metabolic, physiological, and psychological function during exercise. They have gained widespread popularity among both recreational and competitive athletes. As their name implies, MIPSs contain a blend of ingredients, such as caffeine (CAF), beta-alanine (BA), creatine, taurine, nitric oxide agents, and amino acids, as well as herbs and botanicals that are purported to improve exercise training and performance. A few studies [4,14,15,16,17] have examined the effectiveness of MIPSs on endurance exercise performance, but have reported conflicting results
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
