Abstract
The development of a specific inflammation in mice that had been infected by two influenza virus strains, A/chicken/Kurgan/5/2005 (H5N1) and A/Hamburg/2009 MA (H1N1), was studied. We investigated the effect of a non-toxic lipopolysaccharide from Rhodobacter capsulatus PG on the survival and body weight of the mice, production of IgG antibodies, and the induction of pro- and anti-inflammatory cytokines in blood serum. The administration of the R. capsulatus PG lipopolysaccharide was shown to induce interferon-β synthesis, both in healthy and influenza A virus-infected mice, and to promote production of antiviral antibodies in the blood of the influenza-infected animals.
Highlights
Influenza epidemics have, to date, affected millions of people across the world despite the use of recommended vaccines, whose effectiveness proves lower than expected [1, 2]
TLR4 can be activated by damage-associated molecular patterns (DAMPs), which are molecular structures released by virus-infected cells [5]
Deaths of animals in the groups infected with doses of 102/103 and 104/105TCID50 of the H5N1 virus began on days 8 and 6 after infection, respectively
Summary
To date, affected millions of people across the world despite the use of recommended vaccines, whose effectiveness proves lower than expected [1, 2]. The administration of the Rb. LPS into the control mice, as well as infection with a minimum dose of 10 TCID50 of the H5N1 virus, regardless of Rb. LPS administration, did not affect the survival rates of the animals up to the end of the experiment (day 14) (Fig. 3).
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