The effect of a history of a prior art live birth on subsequent live birth rates using linked art cycles

Abstract

ObjectiveTo evaluate the effect of a history of a prior ART live birth (LB) on the subsequent ART live birth rate (LBR, %) using linked cycles for individual women.DesignHistorical cohort study.Materials and MethodsCycles reported to the SART CORS between 2004-08 were included, linked by woman's birthdate, first and last names, and social security number (when present); linkages across clinics also included partner's name and sequence of ART outcomes. Included were cycles with at least one embryo transferred; excluded were research and banking cycles and those using gestational carriers. All remaining cycles were used to calculate the LBR for the 1st LB (no prior ART LB). The study population for the 2nd LB (prior ART LB) was limited to women with an ART LB within 2004-08 and subsequent ART cycles. The LBRs were calculated by ART cycle (1-6), women's age, oocyte source (autologous vs donor), and embryo state (fresh vs frozen).ResultsTabled 1Live Birth Rates (%)AutologousAutologousDonorDonorNo Prior ART LBPrior ART LBNo Prior ART LBPrior ART LBNumber of Women (N)(359,629)(16,351)(31,078)(1,259)Cycle 132.236.149.550.5 224.632.749.853.8 323.129.649.051.1 421.625.849.746.7 518.821.146.948.8 617.924.148.140.7Woman's Age (yrs) <3538.547.151.354.1 35-3729.536.449.756.9 38-4019.826.850.351.4 41-4210.413.949.547.4 ≥433.75.547.950.3Total29.033.149.351.2 Open table in a new tab ConclusionA history of a prior ART LB was associated with a significant improvement in subsequent LBRs; the use of donor oocytes resulted in the highest LBRs, which did not vary by age, cycle or history of ART LB. ObjectiveTo evaluate the effect of a history of a prior ART live birth (LB) on the subsequent ART live birth rate (LBR, %) using linked cycles for individual women. To evaluate the effect of a history of a prior ART live birth (LB) on the subsequent ART live birth rate (LBR, %) using linked cycles for individual women. DesignHistorical cohort study. Historical cohort study. Materials and MethodsCycles reported to the SART CORS between 2004-08 were included, linked by woman's birthdate, first and last names, and social security number (when present); linkages across clinics also included partner's name and sequence of ART outcomes. Included were cycles with at least one embryo transferred; excluded were research and banking cycles and those using gestational carriers. All remaining cycles were used to calculate the LBR for the 1st LB (no prior ART LB). The study population for the 2nd LB (prior ART LB) was limited to women with an ART LB within 2004-08 and subsequent ART cycles. The LBRs were calculated by ART cycle (1-6), women's age, oocyte source (autologous vs donor), and embryo state (fresh vs frozen). Cycles reported to the SART CORS between 2004-08 were included, linked by woman's birthdate, first and last names, and social security number (when present); linkages across clinics also included partner's name and sequence of ART outcomes. Included were cycles with at least one embryo transferred; excluded were research and banking cycles and those using gestational carriers. All remaining cycles were used to calculate the LBR for the 1st LB (no prior ART LB). The study population for the 2nd LB (prior ART LB) was limited to women with an ART LB within 2004-08 and subsequent ART cycles. The LBRs were calculated by ART cycle (1-6), women's age, oocyte source (autologous vs donor), and embryo state (fresh vs frozen). ResultsTabled 1Live Birth Rates (%)AutologousAutologousDonorDonorNo Prior ART LBPrior ART LBNo Prior ART LBPrior ART LBNumber of Women (N)(359,629)(16,351)(31,078)(1,259)Cycle 132.236.149.550.5 224.632.749.853.8 323.129.649.051.1 421.625.849.746.7 518.821.146.948.8 617.924.148.140.7Woman's Age (yrs) <3538.547.151.354.1 35-3729.536.449.756.9 38-4019.826.850.351.4 41-4210.413.949.547.4 ≥433.75.547.950.3Total29.033.149.351.2 Open table in a new tab ConclusionA history of a prior ART LB was associated with a significant improvement in subsequent LBRs; the use of donor oocytes resulted in the highest LBRs, which did not vary by age, cycle or history of ART LB. A history of a prior ART LB was associated with a significant improvement in subsequent LBRs; the use of donor oocytes resulted in the highest LBRs, which did not vary by age, cycle or history of ART LB.