Abstract
The effect of a high cholesterol (HC) diet on lipid levels and oxidative stress in the plasma, liver, and aorta was investigated in rabbits and rats. Rabbits were fed a standard diet containing 1% (w/w) pure cholesterol for 2 months. Rats were fed a diet consisting of the standard diet supplemented with 2% (w/w) pure cholesterol and 0.5% (w/w) cholic acid for 4 months. The HC diet caused significant increases in cholesterol and lipid peroxide levels in plasma and aorta in rabbits. However, plasma cholesterol levels increased only slightly in rats on a HC diet, and there was no effect on aortic cholesterol and lipid peroxide levels. However, the HC diet altered lipid levels and lipid peroxidation as well as glutathione levels and antioxidant enzyme activities in the livers of rabbits and rats in a similar way. Thus, oxidative changes in the plasma and aorta may play an additive role in the formation of atheroma plaques in rabbits after the HC diet.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
