Abstract
MEYER et al. (1948) showed that certain natural and synthetic estrogens in concentrations of 0.2 to 3 × 10−4 M inhibit tissue respiration by attacking the iron compounds in the cytochrome system. The portion of the estrogenic molecule responsible for this inhibition was traced to the free phenolic groups of these compounds. Case and Dickens (1948) described some synthetic estrogens which inhibit the succinoxidase by acting on the cytochrome portion, some which inhibit by acting on the succinic dehydrogenase system, and still others which inhibit the over-all oxidation of succinate but which act neither on the cytochrome oxidase nor the succinic dehydrogenase. Data are herein reported which suggest a-estradiol, some of its esters, and estrone in a concentration of 5 × 10−5 M inhibit oxidation of substrates whose oxidative systems are coenzyme linked but do not inhibit the succinoxidase system. MATERIALS AND METHODS
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
