Abstract
An experiment was conducted to evaluate the effect of a 72-h intertrial interval of 1-Hz brain stimulation on kindling behavior induced by 60-Hz sine-wave stimulation. The effective threshold intensity (ETI) to elicit a kindled response with 60-Hz stimulation was determined on four separate occasions with 15 trials between determinations. Experimental rats were stimulated with 1-Hz sine waves before and after a 60-Hz brain stimulation trial with a 72-h interval between stimulation sessions (1-60-1 group). A second group received only the 60-Hz stimulation on the same trials as those on which the 1-60-1 group was stimulated with 60-Hz current (X-60-X group). In previous experiments with 1, 3, or 24 h between trials, the 1-60-1 group had a gradual increase in the intensity required to elicit a kindled response with 60-Hz current from ETI1 to ETI4 (the suppression effect). However, the 72-h interval produced a decline in ETI values similar to that of the X-60-X group, but not as great. Suppression of kindled behavior on daily trials was not present for the 1-60-1 group, in contrast to results of previous experiments. Apparently, the 72-h interval allowed much of the suppression effect to dissipate.
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