The Effect of 6-Hydroxy-2,2,4-Trimethyl-1,2-Dihydroquinoline on the Intensity of Free Radical Processes and Activity of Oxidative Metabolism Enzymes in Rats with Toxic Liver Injury

Abstract

The effect of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline on markers of hepatocyte cytolysis (aspartate transaminase, alanine transaminase and gamma-glutamyl transpeptidase), parameters reflecting the state of oxidative status (intensity of biochemical luminescence and the content of conjugated dienes), and on activity of oxidative metabolism enzymes (aconitate hydratase, glucose-6-phosphate dehydrogenase, NADP-isocitrate dehydrogenase) was studied in rats with CCl4-induced liver injury. The results obtained in the course of this study demonstrate the ability of the test compound to reduce oxidative stress severity and the degree of liver cell damage, as well as to change activity of aconitate hydratase and NADP-generating enzymes towards control values. 6-Hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline was more effective in normalizing CCl4-induced changes of most analyzed parameters than carsil used as a reference compound. The tendency to normalize the state of oxidative status and enzyme activity of oxidative metabolism can be attributed to hepatoprotective and antioxidant properties of the test compound.