The effect of 6-gingerol on biochemical and histological parameters in cholesterol-induced nonalcoholic fatty liver disease in NMRI mice

Asal Sarrafan,Parichehreh Yaghmaei,Maryam Ghobeh

doi:10.1590/s2175-979020200003181020

Asal Sarrafan, Parichehreh Yaghmaei + Show 1 more

Open Access

https://doi.org/10.1590/s2175-979020200003181020

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Abstract

Fatty liver contains a range of clinical symptoms, including the accumulation of fat in the liver parenchyma and it varies from a simple steatosis to non-alcoholic steatohepatitis and cirrhosis. Using natural therapies has always been a great concern for such health-related diseases. Herein, 6-gingerol, as a natural compound, was applied to treat non-alcoholic fatty liver induced in NMRI mice. The assessment included histological studies of the liver along with measurement of biochemical parameters, including insulin, glucose, adiponectin, leptin, HDL-C (high-density lipoprotein cholesterol), LDL-C (low-density lipoprotein cholesterol), VLDL-C (very low-density lipoprotein cholesterol), Aspartate transaminase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), SOD (superoxide dismutase), and catalase. The results demonstrated that treatment with 6-gingerol (800 mg/kg) modified the fatty liver indices by significantly reducing (p<0.001) the levels of triglyceride, cholesterol, LDL-C, and VLDL-C, glucose, insulin, insulin resistance, and leptin, whereas this treatment notably increased (p<0.001) the levels of liver antioxidant enzymes, HDL-c, and adiponectin. Therefore, 6-gingerol, in a dose-dependent mode, showed capability of improving non-alcoholic fatty liver and could offer a reliable remedy.

Highlights

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and its prevalence has been reported among 20-30% of the population of Western countries (Paschos, Paletas, 2009)
Liver steatosis can be extended to nonalcoholic steatohepatitis (NASH), which is distinguished from simple steatosis by hepatocyte injuries, infiltration
Evaluation of biochemical parameters, including lipid profiles, antioxidant enzymes, adiponectin and leptin hormones as well as histopathologic examinations were performed on the liver

Summary

Introduction

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and its prevalence has been reported among 20-30% of the population of Western countries (Paschos, Paletas, 2009). After receiving 30 days of high-fat diet, the levels of fasting blood glucose, insulin, and insulin resistance (HOMA) showed a significant increase (p

Results

Conclusion