Abstract
The erythropoietic effects of 5α-dihydrotestosterone (5α-DHT) and 5β-dihydrotestosterone (5β-DHT) were compared in the newt, Triturus cristatus carnifex (Laur.). In normal animals, 5β-DHT was more active than 5α-DHT in increasing the number of circulating erythrocytes. In animals rendered completely anemic, only 5β-DHT was effective. The biochemical parameters of δ-aminolevulinic acid synthase and δ-aminolevulinic acid dehydratase of new basophilic erythroblasts, and incorporation of labeled glycine into heme and globin of new polychromatic erythroblasts were enhanced by 5β-DHT. The results are discussed with reference to a direct erythropoietin-independent action of 5β-DHT on erythroid stem cells.
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