Abstract
In the presence of 5-bromodeoxyuridine (BDU), vaccinia-infected HeLa or KB cell cultures develop cytoplasmic foci which stain specifically with fluorescein-coupled rabbit antiserum to vaccinia. These foci are able to incorporate tritiated thymidine on removal of the BDU. The cells yield large quantities of noninfectious, malformed virus particles. Kinetic studies on the establishment of this inhibition, and density gradient analyses of the DNA from BDU-vaccinia, indicate that these abnormalities are a consequence of the incorporation of BDU into the virus DNA. Different poxviruses appear to differ in their susceptibility to BDU inhibition.
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