The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells

In-Song Lee,Dae-Won Kim,Jun-Ho Chang,Seong-Gon Kim,Tae-Woo Kim

doi:10.1186/s40902-021-00326-2

In-Song Lee, Dae-Won Kim + Show 3 more

Open Access

https://doi.org/10.1186/s40902-021-00326-2

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Abstract

Background4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol.MethodIn this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1–100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied.ResultsIn the results, SIRT3 (100 μM at 24 h) and SIRT6 (1–100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h).Conclusion4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.

Highlights

Most clinicians expect successful treatment outcomes after their practice
It is a rare incident, it has been reported that pulpal side effects and root resorption can occur secondary to the orthodontic tooth movement [3]
Excessive stress is known to increases the production of reactive oxygen species (ROS) which is a main reason of inflammation [4,5,6]

Summary

Introduction

Most clinicians expect successful treatment outcomes after their practice. various dental procedures such as oral surgery and orthodontic tooth movement can apply stress to the teeth and surrounding dental tissue including alveolar bone. If tissue fails to manage the stress from surgical treatment, wound healing will be delayed and result in inflammation [1, 2]. It is a rare incident, it has been reported that pulpal side effects and root resorption can occur secondary to the orthodontic tooth movement [3]. The application of anti-oxidant may be Resveratrol is a natural polyphenol and has antioxidant activity [7]. The anti-oxidant activity of 4HR has a similar performance [4,5,6]

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