Abstract
The effect of 3 or 6 weeks feeding of diets containing different fat source and content on deoxycorticosterone 11β-hydroxylase activity in adrenal gland and on plasma corticosterone and leptin concentration in rats
Highlights
Leptin and glucocorticoids are two of the most important peripherally synthesized and secreted hormones that play a crucial role in the regulation of energy balance of an organism
Final body weight and daily body weight gain were found to be significantly higher in rats fed 20% fat diets (P
Fat and fatty acids were higher in rats receiving 20% fat diet as compared to animals fed 10% fat diets (P
Summary
Leptin and glucocorticoids are two of the most important peripherally synthesized and secreted hormones that play a crucial role in the regulation of energy balance of an organism. Fat composition (content of particular fatty acids) influences the composition and functions of cell membranes, as well as intracellular metabolism (Vallette et al, 1991; Innis et al, 1995; Widmaier, 1997; Raatz et al, 2001) These mechanisms seem to play an important role in the regulation of synthesis, secretion and cellular activity of leptin and adrenal hormones (Widmaier, 1997; Heshka et al, 2001)
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