Abstract
(Anesth Analg. 2015;120:1309–1316) Cesarean delivery is the most common major operation in the world. Spinal anesthesia has become the anesthetic technique of choice for both elective and nonelective cases. Without proper treatment or preventive measures, most women experience hypotension, often to such an extent that uteroplacental blood flow is compromised and adverse maternal or fetal effects occur. Previous work by the authors has demonstrated an effect of genetic variants of the β2-andrenoceptor (β2AR; ADRB2 gene) on the ephedrine dose required to maintain blood pressure during spinal anesthesia for cesarean delivery, but the mechanism by which this occurs is unclear.
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