Abstract
BackgroundMigraine is a common neurovascular condition that may be linked to hyperhomocysteinemia. We have previously provided evidence that reduction of homocysteine with a vitamin supplementation can reduce the occurrence of migraine in women. The current study examined the occurrence of migraine in response to vitamin supplementation with a lower dose of folic acid.MethodsThis was a 6 month randomised, double blinded placebo controlled trial of daily vitamin supplementation containing 1 mg of folic acid, 25 mg of Vitamin B6 and Vitamin B12, on reduction of homocysteine and the occurrence of migraine in 300 female patients diagnosed with migraine with aura.ResultsVitamin supplementation with 1 mg of folic acid, did not significantly decrease homocysteine levels (P = 0.2). The treatment group did not show a significant decrease in the percentage of participants with high migraine disability, severity or frequency at the end of the 6 month intervention (P > 0.1).Conclusion1 mg of folic acid in combination with vitamin B6 and B12 is less effective in reducing migraine associated symptoms compared to the previously tested dosage of 2 mg folic acid in combination with 25 mg of vitamin B6 and 400 μg of vitamin B12.
Highlights
Migraine is a common neurovascular condition that may be linked to hyperhomocysteinemia
This study provided some evidence that the effect of vitamin supplementation on reduction of homocysteine levels and migraine disability was influenced by the MTHFRC677T genotype, whereby carriers of the C allele experienced a greater response compared to TT genotypes [13]
European descents living in Australia, having emigrating ancestors within the last 160 years from various locations within the British Isles and other parts of Europe were recruited from East Coast of Australia and were interviewed and completed a detailed questionnaire that was administered through the Genomics Research Centre (GRC)
Summary
Migraine is a common neurovascular condition that may be linked to hyperhomocysteinemia. We have previously provided evidence that reduction of homocysteine with a vitamin supplementation can reduce the occurrence of migraine in women. The TT genotype of the MTHFR C677T SNP has been shown to be associated with a 50 % reduction in enzyme activity and moderately increased levels of circulating homocysteine [7,8,9,10]. This variant and elevated homocysteine levels have been associated with the risk of
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