Abstract
Regular physical activity has a positive effect on the prevention of cellular aging. The present study investigated the effect of 12-week resistance training (RT) on serum levels of Sirtuin-1 (SIRT1), Sirtuin-3 (SIRT3), Sirtuin-6 (SIRT6), Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α), and telomerase enzyme in elderly men. For this purpose, 30 elderly men (age 66.23±0.57years) were randomly divided into two groups: resistance training group (RET, n=15) and control group (CTR, n=15). Participants in RET performed RT protocols with intensity of 60% one-repetition maximum (3×/week, 4 sets of the six exercise circuits). Body composition, physical functioning and, blood samples were assessed before (pre-test) and after (post-test) a 12-week intervention. The results showed that there was a significant increase in serum levels of SIRT1 (P=0.001), SIRT3 (P=0.001), SIRT6 (P=0.02), PGC1-α (P=0.001), and telomerase enzyme (P=0.001) in RET. Also, we found a significant difference between the RET and CTR in serum levels of SIRT1 (P=0.001), SIRT3 (P=0.001), SIRT6 (P=0.037), PGC1-α (P=0.007), and telomerase enzyme (P=0.001). 12-Week RT increased the levels of proteins associated with the biological aging process in elderly men. It seems that the RT may have beneficial effects on cellular senescence and also improved impaired mitochondrial protein and enzymatic functional induced aging.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.