Abstract
1-trans- Δ 9-Tetrahydrocannabinol ( Δ 9-THC) was found to be a potent stimulator of ACTH secretion, as evidenced by depletion of adrena ascorbic acid in rats. Low doses of Δ 9-THC that were inactive in unanesthetized rats stimulated ACTH secretion in pentobarbital anesthetized rats. This observation differentiates Δ 9-THC from other drugs reported to stimulate ACTH secretion. A nonstimulating dose of Δ 9-THC did not block the secretion of ACTH induced by epinephrine. The concentration of adrenal ascorbic acid one hour after a fifth daily injection did not differ significantly from that observed after a single injection.
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