Abstract
The immunoregulatory effect of 1α-hydroxyvitamin D3, a precursor form of active vitamin D3 (1,25-dihydroxyvitamin D3), was examined in three different kinds of experimental systems in mice. Oral administration of 0.05 and 0.2 μg/kg of 1α-hydroxyvitamin D3 augmented the primary immune response induced by immunization with 1 × 107 sheep erythrocytes, although it did not influence a maximal level of antibody formation induced by immunization with 5 × 108 sheep eryhrocytes. The same treatment also restored the immune response depressed by restraint-stress. Furthermore, 1α-hydroxyvitamin D3 suppressed the anti-dinitrophenyl plaque-forming cell response enhanced by colchicine injection to near the normal level. These results suggest that 1α-hydroxyvitamin D3 enhanced or suppressed the immune response through activating helper and suppressor cells in dependence on the magnitude of the response.
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