Abstract
Intestinal calcium transport and renal calcium and phosphate excretion have been measured in normal and prednisolone-treated rats. Prednisolone treatment reduced intestinal calcium transport and increased phosphate excretion, causing a reduction in serum phosphate. Both 1α-hydroxyvitamin D 2 and 1α-hydroxyvitamin D 3 normalized phosphate excretion, whereas 1α-hydroxyvitamin D 3 was not fully effective in serum phosphate. Prednisolone treatment also caused a decreased bone density that was prevented both with 1α-hydroxyvitamin D 2 and 1α-hydroxyvitamin D 3. 1α-hydroxyvitamin D 2 appeared at least as effective as 1α-hydroxyvitamin D 3 in correcting the bone disturbance.
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