Abstract
Our research aimed to show acrylamide’s influence on inflammatory processes, the oxidative stress it causes in the cholinergic system, and the possibility of reducing inflammation via supplementation with α-tocopherol. For this purpose, an in ovo model was used where the embryos were exposed to acrylamide, α-tocopherol and a cocktail of these substances. After 48 h of exposure, we collected brain samples and performed biochemical assays to examine the effect of the chosen substances on oxidative stress (malondialdehyde-MDA and reduced glutathione-GSH) and acetylcholinesterase activity (AChE). The results showed that acrylamide decreased AChE activity in the examined brain samples by about 25% in comparison to the control group, and this effect was decreased by administering α-tocopherol. The concentration of malondialdehyde significantly increased in the group given acrylamide, while, in the group with α-tocopherol, the observed concentration was lower in comparison to the control group. Moreover, a decrease in glutathione concentration was observed after the administration of acrylamide; however, the protective effect of α-tocopherol was only slightly visible in this case. In conclusion, α-tocopherol minimizes the harmful effects of acrylamide on AchE, and it can minimize the concentration of MDA.
Highlights
Published: 31 January 2022The harmful effect of acrylamide (ACR) has already been well documented, and since the 1990s, many studies have been carried out to analyze the carcinogenicity, toxicity and neurotoxicity of acrylamide
Our research aims to show the influence of acrylamide on inflammatory processes causing oxidative stress in the cholinergic system
ACR action in the organism leads to the oxidative stress, inflammation, apoptosis and damage to DNA [3]
Summary
Published: 31 January 2022The harmful effect of acrylamide (ACR) has already been well documented, and since the 1990s, many studies have been carried out to analyze the carcinogenicity, toxicity and neurotoxicity of acrylamide. Our research aims to show the influence of acrylamide on inflammatory processes causing oxidative stress in the cholinergic system. Our focus was on investigating the possibility of reducing ACR harmful effects via supplementation with α-tocopherol. Acrylamide is an organic compound with the formula C3 H5 NO; it is formed due to the reaction between amino acids and reducing sugars in the Maillard reaction. It is formed in significant amounts during the thermal treatment, frying or baking of carbohydratecontaining food products, starches. ACR action in the organism leads to the oxidative stress, inflammation, apoptosis and damage to DNA [3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
