The effect of α-amanitin on the synthesis of polyoma specific RNA

Abstract

α-Amanitin inhibits the synthesis of polyoma specific RNA in cultured mouse kidney cells and in a coordinated way the synthesis of RNA stimulated by the presence of the virus. Late in infection, there is a preferential inhibition of polyoma mRNA synthesis. The results point to the involvement of host RNA polymerase II(B) in polyoma DNA transcription and suggest a possible modification of the enzyme late in infection.