Abstract
Cultured myocytes from neonate rats were subject to increasing doses of dl-, d- or l-propranolol or dl-atenolol, and the intrinsic heart rates were measured. Both propranolol isomers and racemate stopped beating activity at very high concentrations (10 −3 m) while atenolol did not. The results are interpreted to indicate that constant β-adrenoceptor stimulation is not an obligatory requirement for maintenance of spontaneous beating in this system as has been suggested.
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