Abstract
Δ1,6 T.H.C. caused excitement followed by pronounced behavioural depression and catalepsy in rats when given at a dose of 100 mg/kg i.p. (Lower doses were less effective in producing these responses). Some 4 hr after administration, the animals became aggressive when disturbed. Ten hr after injection catalepsy was absent, the animals were slightly hyperactive-but no longer aggressive. Despite the pronounced behavioural changes caused byΔ1,6 T.H.C., the concentration and turnover of brain biogenic amines remained unaffected. There was a slight decrease in brain and blood tyrosine and in brain γ-aminobutyric acid levels.
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