Abstract
The mannose receptor recognizes the patterns of carbohydrates that are present on infectious agents and associated with various biological glycoproteins. Recent advances emphasize the participation of this multilectin-type receptor in antigen presentation. In this issue, Deslée et al ( p 763 ) demonstrated that the glycoprotein Der p 1 (the common house dust mite aeroallergen) can be taken up by human dendritic cells via the mannose receptor. Indeed, by using rhodamine-labeled Der p 1, they showed that monocyte- derived dendritic cells uptake Der p1 in a dose-, time-, and temperature-dependent manner and that the process observed in house dust mite –allergic patients is similar to that observed in healthy donors.
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