Abstract
The soft tissue sealing at the transmucal portion of implants is vital for the long-term stability of implants. Hydrogenated titanium nanotubes (H2-TNTs) as implant surface treatments were proved to promote the adhesion of human gingival fibroblasts (HGFs) and have broad usage as drug delivery systems. Bovine serum albumin (BSA) as the most abundant albumin in body fluid was crucial for cell adhesion and was demonstrated as a normal loading protein. As the first protein arriving on the surface of the implant, albumin plays an important role in initial adhesion of soft tissue cells, it is also a common carrier, transferring and loading different endogenous and exogenous substances, ions, drugs, and other small molecules. The aim of the present work was to investigate whether BSA-loaded H2-TNTs could promote the early adhesion of HGFs; H2-TNTs were obtained by hydrogenated anodized titanium dioxide nanotubes (TNTs) in thermal treatment, and BSA was loaded in the nanotubes by vacuum drying; our results showed that the superhydrophilicity of H2-TNTs is conducive to the loading of BSA. In both hydrogenated titanium nanotubes and non-hydrogenated titanium nanotubes, a high rate of release was observed over the first hour, followed by a period of slow and sustained release; however, BSA-loading inhibits the early adhesion of human gingival fibroblasts, and H2-TNTs has the best promoting effect on cell adhesion. With the release of BSA after 4 h, the inhibitory effect of BSA on cell adhesion was weakened.
Highlights
Peri-implantitis is the most common complication of oral implantation, with incidence of 8.9–43.3% [1]
The purpose of this study was to investigate whether Bovine serum albumin (BSA)-loaded H2 -titanium dioxide nanotubes (TNTs) could
The hypothesis of this study was that BSA-loaded H2 -TNTs have beneficial surface properties, The morphology of each sample was observed by SEM (Figure 1)
Summary
Peri-implantitis is the most common complication of oral implantation, with incidence of 8.9–43.3% [1]. Previous studies proposed that the long-term stability of oral implant could be promoted by enhancing osseointegration. A large number of studies found that soft tissue sealing at the transmucosal part of implants played a important role in reducing the inflammation around the implant, which could enhance the stability of the implant as well. The soft tissue around the implant is weaker than that of natural teeth, which is more prone to the penetration of bacteria [2]. If the soft tissue sealing is enhanced, the risk of bacteria invasion and apical migration of the junctional epithelium can be reduced, which can further lower the risk of peri-implant inflammation [3,4]. Many studies have focused on surface modification of biomaterial to enhance the bioactivities of soft tissue cells [6]
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