The dynamics of some human skin biophysical parameters in the process of optical clearing after hyperosmotic solutions topical application

Abstract

Goal of the study. To study changes of certain biophysical parameters of human skin in the process of optical (immersion) clarification under the effect of hyperosmotic agents. Materials and methods. Measurements were made on the skin (on the right and left hands) of 18 female volunteers aged 17-38. Biophysical parameters of the skin and its phototype were determined with the use of Soft Plus, a device for the diagnostics of the skin condition (Callegari, Italy), and erythema melanin meter (EMM-002E, Russia). 30%, 40% and 50% aqueous glucose solutions as well as 50% aqueous-alcoholic (30°) fructose solution were used as hyperosmotic (dehydrating) study agents. Results. It was revealed that the extent and time of skin dehydration mostly depend on the method of application of the immersion agent and its composition. Depending on the applied technology, it is possible to achieve both a decrease and an increase in the skin moisture extent, which is related to the physiological response of the skin to the occlusion and osmotic action of the agents. 50% aqueous-alcoholic fructose solution appears to be the most efficient dehydrating agent of all study agents.