Abstract
Objective: Mitochondria play an important role in oocyte maturation and early embryo development, producing the ATP and so the energy for many cellular activities, and they also carry a small complement of mitochondria-specific genes. In current efforts to ‘rescue’ aged oocytes by the transfer of ooplasm or karyoplasts, the coincidental transfer of mitochondria and so possible creation of heteroplasmy has become a matter of some concern. Therefore, we have investigated the spatial distribution of mitochondria at different maturational stages in human and mouse oocytes, using a fluorescent marker.
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