Abstract
<abstract> COVID-19 is pandemic worldwide, and different countries have adopted different measures to stop the spread of the epidemic. In order to study the impact of quarantining close contacts on the spread of coronavirus disease 2019 (COVID-19), based on data published by Beijing Municipal Health Commission, World Health Organization (WHO) and Korea Central Disaster Control Headquarters (KCDC), SEIR dynamic models of virus transmission in Beijing and South Korea were set up respectively; the Genetic algorithm was used to fit the important parameters such as transmission rate, recovery rate and quarantine rate; calculated the control reproduction number; we discuss the impact of quarantining close contacts on daily new cases in South Korea, the daily new cases decrease after a week, and drop to 16.93 after 30 days. When close contacts were quarantined, the maximum value of daily new cases $ I_{max}=57.4 $ obtained by simulation is only 13% of the actual maximum value actual $ I_{max}=441 $; the influences of different quarantine rates and the number of the susceptible on the number of daily new cases are also discussed, the quarantine of close contacts has significant effect on reducing the number of daily new cases compared with less stringent control measures. Vigorous control measures reduce the number of daily new cases to single digits in just 17 days in Beijing, effectively curbing the transmission of COVID-19. It has vital significance for the prevention and control of the epidemic in other countries and regions. </abstract>
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