The dynamic characteristics of magnetic source imaging of recognizing negative expression in major depressive disorder

Abstract

Objective To explore the features of functional networks about recognizing dynamically negative expression using magnetoencephalography (MEG) and the paradigm of expressional experiment,and to examine its neurological basis. Methods Twelve depressed patients and 12 age- and educationmatched healthy controls participated to recognize the dynamically negative expression during MEG scanning. Results Compared with healthy controls, the abnormally activities regions in depressed patients during different time periods were separately as follow: the bilateral uncus gyrus, bilateral superior temporal gyrus, right middle frontal gyrus, right amygdale, right temporal sub-gyrus, left angular gyrus, left caudate nucleus head, left inferior occipital gyrus, right parahippocampal gyrus, left fusiform gyrus, bilateral precuneus, left anterior lobe culmen, and left cuneus ( P＜0.01, uncorrected). Conclusion Abnormal brain activity is distributed extensively in depressed patients during recognizing dynamically negative expression, which may prompt the features of functional networks about recognizing dynamically negative expression. Key words: Depression; Magnetoencephalography; Negative emotion recognition