Abstract
OBJECTIVE: The aim of this study was to examine caveolin‐I expression in mouse uterus during the implantation and to explore its effect on implantation. METHODS: To detect the mRNA expression of caveolin‐1 in uterus with semiquantitative reverse transcriptase‐polymerase chain reaction technique. At the same time, to detect the expression of caveolin‐1 in uterus with immunohistochemistry technique. RESULTS: The mRNA expression of caveolin‐1 was significantly higher in endometrial decidual tissue on day 9.5 of pregnancy than that of day 3.5 to 7.5 of pregnancy and non‐pregnancy endometrial decidual tissue. The differences were significant (P<0.05). A strong level of caveolin‐1 expression was observed in the decidualized cells and vascular endothelial cells at mesometrium side from days 4.5 to 9.5 of pregnancy. The positive expression of caveolin‐1 can be observed in cytotrophoblast cell but not in syncytotrophoblast cell. CONCLUSION: In conclusion, these results suggest that caveolin‐1 expression may be closely related to embryo implantation and decidualization by regulating vascular permeability and angiogenesis.
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