The dynamic changes and its clinic values of serum S100B、 NSE、 MBP in patients with carbon monoxide poisoning

Abstract

Objective To explore the clinical significance and the dynamic changes of serum S 100B, neuron specific Enolase（NSE）, myelin basic protein（MBP） in patients with carbon monoxide poisoning. Methods 185 carbon monoxide poisoning patients and 30 healthy volunteers were enrolled in this study. The serum S 100B, NSE, MBP at admission were measured in all cases, and in the following two days for the 60 moderate and severe patients.Rasulta The moderate and severe patients had higher S100B, NSE level at admission than the controls and the mild patients, but MBp level at admission were significantly different among the three groups.Compared with the survivor group,death group had higher S100B, NSE, MBP in all three days.In death group, both S100B and NSE increased remarkably in the second day and kept higher level in the third day, but MBP level were not significantly different in all three days for the death group. For the survivors group, no difference were found for these index among the three days.Conclusions The serum MBP level at admission was related with the severity of carbon monoxide poisoning.Dynamic analysis of serum NSE and S100B could effectively evaluate the progress and prognosis of the patients with carbon monoxide poisoning. Key words: Carbon monoxidepoisoning; S100B; NSE; MBP; Prognosis