Abstract
The effects of poldine methylsulphate on the basal and stimulated output of acid from the stomach when given for 30 to 279 days in doses sufficient to produce mild continuous side effects have been studied in 27 patients with duodenal ulceration. Twelve hours after the last dose of poldine the mean reduction in stimulated acid output is 36% (P > 0.01). Twenty-four hours after the last dose of poldine the proportion of patients showing a reduction is smaller, the mean reduction being 12% (P > 0.4). The fact that reduction in acid output may last for 7 days should be allowed for in measuring gastric secretion in patients already receiving treatment with this drug.
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