Abstract
Recent papers by Cornell 1 and from this laboratory 2 have shown that B. welchii produces long standing infections in rabbits, accompanied by an anemia which resembles pernicious anemia in man. Kahn and Torry 3 produced similar changes in monkeys with B. welchii toxin. From a quantitative study of the type of anemia produced in rabbits by B. welchii toxin, by tetanolysin, streptolysin and pneumolysin, we have already shown 2 that while similar degrees of anemia, as measured by decrease in circulating red cells and in hemoglobin percentage, may be produced by varying the dosage of these four hemotoxins only B. welchii toxin produces a measurable anisocytosis. It was also shown (Reed and Orr)2 that in the in vitro hemolysis by these four toxins only B. welchii produces a definite change in the structure of the red cells which resist hemolysis. Kahn and Torry 3 found that monkeys developed an immunity to B. welchii toxin so that progressive doses became less effective and finally ceased to produce a reaction. Similar reactions might be expected from B. welchii toxemia in other animals including man. The recurrence then of toxemia from a reinoculation with toxin or
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
