Abstract

The Dundee Resource for Sequence Analysis and Structure Prediction (DRSASP; http://www.compbio.dundee.ac.uk/drsasp.html) is a collection of web services provided by the Barton Group at the University of Dundee. DRSASP's flagship services are the JPred4 webserver for secondary structure and solvent accessibility prediction and the JABAWS 2.2 webserver for multiple sequence alignment, disorder prediction, amino acid conservation calculations, and specificity‐determining site prediction. DRSASP resources are available through conventional web interfaces and APIs but are also integrated into the Jalview sequence analysis workbench, which enables the composition of multitool interactive workflows. Other existing Barton Group tools are being brought under the banner of DRSASP, including NoD (Nucleolar localization sequence detector) and 14‐3‐3‐Pred. New resources are being developed that enable the analysis of population genetic data in evolutionary and 3D structural contexts. Existing resources are actively developed to exploit new technologies and maintain parity with evolving web standards. DRSASP provides substantial computational resources for public use, and since 2016 DRSASP services have completed over 1.5 million jobs.

Highlights

  • The Dundee Resource for Sequence Analysis and Structure Prediction (DRSASP; http://www.compbio.dundee.ac.uk/drsasp.html) is a collection of web services provided by the Barton Group at the University of Dundee

  • DRSASP resources are available through conventional web interfaces and application programming interfaces (APIs) but are integrated into the Jalview sequence analysis workbench, which enables the composition of multitool interactive workflows

  • Other existing Barton Group tools are being brought under the banner of DRSASP, including NoD (Nucleolar localization sequence detector) and 14-3-3-Pred

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Summary

Introduction

Thiago Britto-Borges, Section of Bioinformatics and Systems Cardiology, Department of Internal Medicine III and Klaus Tschira Institute for Integrative Computational Cardiology, University of Heidelberg, Germany. The flood of sequence data across all species continues to grow in rate and volume. While there are many challenges in managing these large datasets, the major hurdle is to use the raw sequence data to inform our knowledge and understanding of biological systems. In order to achieve this goal, accurate and reliable software tools are required to make structural and functional predictions from the sequence data. Over 30 years, our group has developed innovative software packages, web servers, Protein Science. Over 30 years, our group has developed innovative software packages, web servers, Protein Science. 2019;1–21

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