Abstract
The ductus arteriosus is a large vessel which connects the pulmonary trunk with the aorta. During fetal life it serves together with the foramen ovale as a shunt at cardiac level. Due to a complex regulatory mechanism it is capable of maintaining patency during fetal life and of rapid closure after birth. However, in premature neonates ductal patency frequently persists, an occurrence which may even be favourable in some situations. Recent investigations on the ductus arteriosus have provided new information about the regulatory mechanisms involved with its function. Initially, most studies on the fetal ductus arteriosus were conducted in animals. With the introduction of the combined use of two dimensional real-time and Doppler ultrasound systems the opportunity became available to study blood flow within the ductus arteriosus in the human fetus and neonate in a noninvasive manner. The increasing use in obstetric care of cyclo-oxygenase inhibitors for tocolysis and for prevention of the development of pregnancy induced hypertension and pre-eclampsia justifies the re-evaluation of the potential adverse effects of these drugs on the ductus arteriosus.
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