Abstract
In pancreatic islets, nitric oxide (NO) produced on exposure to cytokines mediates beta-cell injury leading to diabetes mellitus. On the other hand, L-arginine-derived NO may participate in the signal transduction pathway of physiological insulin secretion. This review focuses on the dual role of NO as a mediator of physiological and pathophysiological processes in pancreatic islets.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have