Abstract
Inflammation may have controversial effects, it may be able to eradicate tumor cells and also, when it becomes chronic it can promote tumor growth. Resolution of inflammation and clearance of inflammatory cells remains a process that should to be studied more extensively. Here, we review our results using a lung adenocarcinoma LP07 that develops paraneoplastic syndromes such as hypercalcemia, cachexia and leukocytosis during its evolution. The role and activation of polymorphonuclear neutrophils were studied during tumor development and the cytotoxicity of splenic lymphocytes was determined. The treatment with non steroid anti-inflammatory drugs (NSAIDs) resulted in a reduction of tumor and metastases. The target of NSAIDs by COX-2 antisense transfection of LP07 cells was investigated. The results showed that NFκB was the main target of NSAIDs. The production of IL-1β and IL-6 cytokines and the proteolytic enzyme MMP-9 during tumor growth were also investigated. In this tumor model chronic inflammation induced by the tumor plays an important role in its progression.
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