The Dual Detection of Uric Acid and Paracetamol in Biological Fluids with the Modified “Green” Sensor through the Electropolymerization

Abstract

The PM material was effectively synthesized in this study via electropolymerization. The electrochemical characteristics of glassy carbon electrodes (GCE)@RGO were examined after the PM was polymerized onto its surface to create PM-RGO/GCE with the support of the CV technique. Furthermore, employing this modified electrode, URA and PCM were examined by applying CV and DPV electrochemical techniques. In comparison to employing the RGO/GCE, the modified PM-RGO/GCE electrode showed good responsiveness toward URA and PCM applying the DPV technique, with LOD values of 0.040 μM for URA, and 0.025 μM for PCM. The linear concentrations ranged from 0.06 to 1 μM. These factors like Na+, SO4 2−, Ca2+, Cl−, NH4 +, NO3 − ions, ascorbic acid, dopamine, hypoxanthine and xanthine, did not interfere during the modified electrode’s operation. Within this paper, it is worth emphasizing that these analytical processes for the URA and PCM in actual sample solutions are more dependable than the HPLC method.