Abstract
MITOCHONDRIA Mitochondria are very dynamic organelles and undergo regular fusion and fission reactions. Fission involves the dynamin GTPase Drp1, a cytosolic enzyme that is recruited to mitochondria, where it oligomerizes and contracts to cause the mitochondrial membrane to constrict. Ji et al. studied Drp1 dynamics in live cells. Contrary to current models, fission sites did not directly recruit Drp1 from the cytoplasm. Instead, mitochondria progressively added Drp1 molecules to form oligomers. Most mature Drp1 oligomers did not mediate fission. When the authors experimentally induced mitochondrial fission, actin and Drp1 accumulated sequentially at specific mitochondrial fission sites. Thus, the assembly of fission-productive Drp1 oligomers involves recruitment, maturation, and actin-dependent conversion. eLife 10.7554/eLife.11553 (2015).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
