The dorsal hippocampus and dorsolateral striatum play complementary roles in the learning of cue- and spatial-based navigation in the Morris water maze

Abstract

Event Abstract Back to Event The dorsal hippocampus and dorsolateral striatum play complementary roles in the learning of cue- and spatial-based navigation in the Morris water maze Claudio Da-Cunha1*, Edmar Miyoshi2, Evellyn C. Wietzikoski1, Mariza Bortolanza1, Suelen Boschen1 and Newton S. Canteras3 1 UFPR, Laboratorio de Fisiologia e Farmacologia do Sistema Nervoso Central, Departamento de Farmacologia, Brazil 2 UEPG, Departamento de Ciencias Farmaceuticas, Brazil 3 USP, Departamento de Anatomia, Instituto de Ciencias Biomedicas-3, Brazil The multiple memory systems theory proposes that the hippocampus and the dorsal striatum are the core structures of the spatial/relational and stimulus-response (S-R) memory systems, respectively. This theory is supported by double dissociation studies showing that the spatial and cued (S-R) versions of the Morris water maze are impaired by lesions in the dorsal hippocampus and dorsal striatum, respectively. In the present study we further investigated this hypothesis by testing whether adult male Wistar rats bearing double and bilateral electrolytic lesions in the dorsal hippocampus and dorsolateral striatum were as impaired as rats bearing single lesions in just one of these structures in learning both versions of the water maze. Such prediction, based on the multiple memory systems theory, was not confirmed by our findings. Although, compared to the controls, the latency to find the escape platform of the animals with single lesions decreased more slowly in one of the versions, the animals with double lesions presented no improvement at all in both versions of the water maze. These results suggest that both the dorsal hippocampus and the dorsolateral striatum are needed for the learning of cue- and spatial-based navigation in the water maze. Therefore, it seems that, instead of independent systems supporting S-R or spatial learning, the hippocampus and dorsal striatum play critical roles in these two kinds of learning. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Da-Cunha C, Miyoshi E, Wietzikoski EC, Bortolanza M, Boschen S and Canteras NS (2009). The dorsal hippocampus and dorsolateral striatum play complementary roles in the learning of cue- and spatial-based navigation in the Morris water maze. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.124 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Jun 2009; Published Online: 08 Jun 2009. * Correspondence: Claudio Da-Cunha, UFPR, Laboratorio de Fisiologia e Farmacologia do Sistema Nervoso Central, Departamento de Farmacologia, Curitiba, Brazil, dacunha@pq.cnpq.br Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Claudio Da-Cunha Edmar Miyoshi Evellyn C Wietzikoski Mariza Bortolanza Suelen Boschen Newton S Canteras Google Claudio Da-Cunha Edmar Miyoshi Evellyn C Wietzikoski Mariza Bortolanza Suelen Boschen Newton S Canteras Google Scholar Claudio Da-Cunha Edmar Miyoshi Evellyn C Wietzikoski Mariza Bortolanza Suelen Boschen Newton S Canteras PubMed Claudio Da-Cunha Edmar Miyoshi Evellyn C Wietzikoski Mariza Bortolanza Suelen Boschen Newton S Canteras Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.