Abstract
This article reported the distribution of DNase-1 sensitive regions in genomes of three Burkitt’s lymphoma cell lines, P3HR-1, Raji and Ramos cell lines using a new method ofin situ nick translation of chromosomes substituted completely by BrdU. The results showed that theBlym locus on chromosomes in three cell lines and thec-myc locus on chromosomes in P3HR-1 were the DNase-1 sensitive regions and found that the rearrangemental sites of chromosomes present in three Burkitt’s lymphoma cell lines were sensitive to DNase-1 digestion, indicating thatc-myc, bcl-1 genes located at the rearrangemental sites and theBlym gene in Burkitt’s lymphoma are the active genes having the capability of expression.
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