Abstract
Abstract In vivo, phage Mu-1 is only slightly sensitive to several restriction enzymes. This can be explained by a nonspecific modification function of Mu that acts on Mu-DNA and on other DNA's. Mutants of Mu unable to perform this modification ( mom mutants) were isolated, and one mutation was localized on the Mu genome. In addition, the Mu modification function seems to be expressed at a higher level after induction of a Mu prophage than after lytic infection with Mu. Control of mom activity may be related to G-segment inversion as discussed below.
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