Abstract
The relative amounts of soluble and ribosomal RNA in bacterial cells growing at various growth rates have been determined by sucrose gradient analysis of phenol-prepared RNA. The proportion of 4 s RNA as per cent of total RNA was found to vary from about 20% in cells growing rapidly at a rate of 2·4 doublings/hr to about 65% in cells growing at a rate of 0·2 doublings/hr. The soluble RNA/DNA ratio is a constant irrespective of the growth rate. In contrast, the ribosomal RNA/DNA ratio increases proportionately with the growth rate. These observations suggest that the soluble RNA and ribosome fractions are regulated independently. The rates of protein synthesis per unit weight of RNA have been determined over the same range of growth rates. The rate of protein synthesis per unit weight of ribosomal RNA is a constant at all growth rates.
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