Abstract
Compartmentation of intracellular chloride (Cli−) in muscle of lobster walking leg was shown by two independent methods: (1) after equilibration in low-Cl− medium, Cli− was reduced from 85 to 30 mM/kg cells; (2) after equilibration in medium containing 36Cl, a similar concentration of Cli−, 32.5 mM/kg cells, remained unexchanged with the isotope. The Cl− remaining in muscles in low-Cl− medium was essentially nonexchangeable, showing that the immobile compartment of Cli− is independent of changes in the mobile compartment of Cli− and of the external concentration of Cl−. The mobile compartment varied linearly with external Cl−, with a constant ratio of about 10:1. Sodium appeared to be distributed similarly to chloride, both qualitatively and quantitatively. From experiments on the relation between external K+ concentration and the resting membrane potential, and on the exchangeability of intracellular K+, the possibility of compartmentation of Ki+ is discussed.
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