Abstract
The present study was aimed to analyze the frequencies of human leukocyte antigen ( HLA)-A, -B, and - DRB1 alleles and A-B-DRB1, A-B, A-DRB1 and B-DRB1 haplotypes in inhabitants of Guizhou province, China. All samples were typed in the HLA-A,-B, and - DRB1 loci using the polymerase chain reaction-reverse sequence specific oligonucleotide probe (PCR-rSSOP) method and HLA polymorphisms were analyzed. A total of 18 HLA-A, 31 HLA-B, and 13 HLA-DRB1 alleles were found in the Guizhou population. The first two frequent alleles in the HLA-A, -B, and - DRB1 loci were A*11(30.72%) and A*02(30.65%), B*40(16.27%) and B*46(16.27%), and DRB1*09(15.91%) and DRB1*15(13.51%), respectively. The most common haplotype was A*02-B*46- DRB1*09(5.59%) in A-B-DRB1, A*02-B*46(11.73%) in A-B, B*46- DRB1*09(7.49%) in B-DRB1, and A*02- DRB1*09(8.08%) in A-DRB1. Some haplotypes with strong linkage disequilibrium (LD) were found not only in the common haplotypes, such as A*33-B*58, B*30-DRB1*07, and B*33-DRB1*03, but also in the rare haplotypes, such as A*01-B*37, B*37-DRB1*10, and A*01-DRB1*10. Guizhou inhabitants shared some characteristics of the Southern Chinese population but also had their own unique features. Overall, HLA polymorphism in Guizhou population was more consistent with that of Chengdu population than that of other populations in China.
Highlights
Guizhou province is located in the southwest of China
We examined the frequencies of HLAA, -B, and -DRB1 alleles in a total of 2,879 persons residing in the Guizhou province of China
The P value was used to measure the magnitude of the deviation in a population sample, if a P value greater than 0.05, indicated that the population were consistent with HardyWeinberg equilibrium[10], which meant that the population was random and the sample size was adequately large[11,12]
Summary
Guizhou province is located in the southwest of China. It adjoins Sichuan province and Chongqing municipality to the north, Yunnan province to the west, Guangxi province to the south and Hunan province to the east. Guizhou is a mountainous province; while it is mountainous in the west, the eastern and southern regions are relatively flat. Guizhou covers an area of over 176,000 square kilometers with a total population of more than 35,245,000. Guizhou is one of the provinces that contain the greatest number of minority groups. There are 49 ethnic groups living there, with minorities making up about 38% of the population and their compositions rank third in China after Yunnan Province and Xinjiang Autonomous Region
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