Abstract
Mitochondria suspended in aqueous solutions containing albumin and bilirubin can preferentially sequester bilirubin from the aqueous phase of such suspensions. The association of bilirubin with mitochondria is favored when the molar ratio of bilirubin to albumin is above 1. The rate of association of bilirubin with mitochondria is increased in hypertonic media or after the addition of organic anions which compete with bilirubin for protein binding. The concentration ratio of bilirubin to albumin at which bilirubin distribution exceeds the albumin space in vitro corresponds to in vivo concentrations of bilirubin and albumin of 20 mg. and 3 Gm. per 100 ml. of plasma, respectively.
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