Abstract
As part of a study to determine the binding of cadmium ions to cellular components of the lung and kidney after inhalation of its oxide aerosol, the retention and distribution of cadmium, zinc, and copper were measured as a function of exposure level and time. The animals were sacrificed on a periodic basis and their tissues analyzed for the metals with the aid of atomic absorption spectrophotometry. The retention of cadmium, based on calculations of the amount inhaled, was measured and found to be relative to the ambient concentration within the inhalation chamber. The concentrations of the metals in each organ were primarily related to the length of the exposure. Homogenization of each organ, followed by subcellular fractionation through differential centrifugation, was used to demonstrate the steady increase in concentration of all 3 metals within the cytoplasm of the cells.
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