Abstract
Summary Our observations suggest that urease activity is located in both the parietal and the mucoid cells of the cat and dog gastric mucosa. In the parietal cells urease was present in all the investigated animals. Activity was higher on the lesser curvature than the greater curvature. Stimulation of secretion by feeding and histamine increased urease activity in the parietal cell zone. The urease activity in the fundic surface epithelium was very low in a resting state, but increased considerably during secretory stimulation. About two-thirds of the animals investigated exhibited urease activity in the pyloric mucosa. The urease activities observed at pH 7.9 and 5.3 were similar in both the fundus and the pylorus. The present data support the view that urease is of cellular origin and that bacterial sources cannot account for its occurrence at subepithelial levels.
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