Abstract
SummaryA technique was developed which provided large numbers of viable pulmonary alveolar macrophages from the mouse.These cells were labelled in vitro with 198Au and their distribution following intravenous injection in isologous strain mice was determined and compared with that of peritoneal macrophages in the same experimental system.Those transfused cells which localised in the liver were found to be indistinguishable both morphologically and functionally from indigenous Kupffer cells.In general, pulmonary alveolar and peritoneal macrophages were distributed in a very similar manner, although alveolar macrophages did not accumulate in the spleen in as high a concentration as did peritoneal macrophages.
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