Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with unclear genetic foundation. Genetic association studies with large cohort were extensively performed but not for East Asian population especially for Chinese Population. To date, little is known about racial disparities in the genetic landscape of PDAC. Significantly higher rate of EGFR mutation in Chinese lung cancer patients bring about a new era of lung cancer treatment, leading to a remarkably improved survival. Therefore, understanding the distinct genetic features of PDAC in Chinese population is warranted and could possibly change the paradigm of PDAC management.

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