Abstract
BackgroundRecent data indicate that the cell adhesion proteins are abnormally regulated in several human cancers and the expression of the cell adhesion proteins E-cadherin and claudin proteins is involved in the etiology and progression of cancer. It is clear that these protein represent promising targets for cancer detection, diagnosis, and therapy.MethodsTo explore the expression distinction of the cell adhesion proteins claudin-10,-14,-17 and E-cadherin in the adjacent non-neoplastic tissues and gastric cancer tissues, 50 gastric cancer tissues and 50 samples of adjacent non-neoplastic tissues adjacent to the tumors were examined for expression of claudin-10,-14,-17 and E-cadherin by streptavidin-perosidase immunohistochemical staining method.ResultsThe positive expression rates of E-cadherin in gastric cancer tissues and adjacent non-neoplastic tissues were 32% and 74% respectively (P < 0.01). The positive expression rates of claudin-10 in gastric cancer tissues and adjacent non-neoplastic tissues were 24% and 72% respectively (P < 0.01). The positive expression rates of claudin-17 in gastric cancer tissues and adjacent non-neoplastic tissues were 18% and 70% (P < 0.01). In contrast, the positive expression rates of claudin-14 in gastric cancer tissues and adjacent non-neoplastic tissues were 58% and 24% respectively (P = 0.015 < 0.05) Thus in our study, the expression of E-cadherin, claudin-10, and claudin-17 was down-regulated in gastric cancer tissue while the expression of claudin-14 was up-regulated. Correlations between claudins and E-cadherin expression with lymphatic metastasis were observed.ConclusionOur study reveals that the expression of E-cadherin, claudin-10, and claudin-17 were down-regulated in gastric cancer tissue while the expression of claudin-14 was up-regulated and correlation between claudins and E-cadherin expression with lymphatic metastasis were observed.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1475928069111326.
Highlights
Cell-cell adhesion junction is an essential necessity during cell differentiation, tissue development, and tissue homeostasis [1]
The expression of claudin-10, claudin-17 and E-cadherin was reduced in gastric cancer In our study, E-cadherin expression was evaluated in the membranes of 50 gastric cancers tissues and 50 specimens containing gastric tissue adjacent to the carcinoma
We find a correlation between claudin-17 and claudin-10 (The Chi-square test/Chi-Square Goodness-of-Fit Test, φ = 0.693, P
Summary
Cell-cell adhesion junction is an essential necessity during cell differentiation, tissue development, and tissue homeostasis [1]. It is reported that the development of malignant tumors, in particular the transition from benign lesions to invasive, metastatic cancer, is characterized by a tumor cell’s ability to overcome cell-cell adhesion and to invade in tumor cell lines and in in vivo tumor model systems and loss of E-cadherin expression during tumor progression has been observed in numerous human carcinomas [5]. Malignant cells accompanied with cell-adhesion abnormity and frequently display structural and functional disruption of the tight junctions [20]. Recent data indicate that the cell adhesion proteins are abnormally regulated in several human cancers and the expression of the cell adhesion proteins E-cadherin and claudin proteins is involved in the etiology and progression of cancer. It is clear that these protein represent promising targets for cancer detection, diagnosis, and therapy
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